Protective immunity to liver-stage malaria

Protective immunity to liver-stage malaria

Despite decades of research and recent clinical trials, an efficacious long-lasting preventative vaccine for malaria remains elusive. This parasite infects mammals via mosquito bites, progressing through several stages including the relatively short asymptomatic liver stage followed by the more persistent cyclic blood stage, the latter of which is responsible for all disease symptoms. As the li...

Protective immunity to pre-erythrocytic stage malaria.

The development of a vaccine against malaria is a major research priority given the burden of disease, death and economic loss inflicted upon the tropical world by this parasite. Despite decades of effort, however, a vaccine remains elusive. The best candidate is a subunit vaccine termed RTS,S but this provides only partial protection against clinical disease. This review examines what is known...

Against Liver-Stage Malaria The Complexity of Protective Immunity

Protective immunity against malaria liver stage after vaccination with live parasites.

Despite nearly 100 years of research and control efforts, malaria remains one of the most important infectious diseases. An efficient vaccine would be a powerful to tool to reduce mortality and morbidity. Experimentally, induction of sterile immunity in humans after vaccination with attenuated sporozoites has been obtained. This observation has spurred the search for subunit vaccines that aim t...

Chloroquine Inhibits Protective Immunity to Mouse Malaria

271 Received July 24, 2014; revised and accepted November 5, 2014. Published online December 4, 2014; doi: 10.1620/tjem.234.271. Correspondence: Yaming Cao, Department of Immunology, College of Basic Medical Sciences, China Medical University, No. 92 Beier Road, Heping District, Shenyang, Liaoning 110001, P.R. China. e-mail: [email protected] Early Treatment with Chloroquine Inhibits the Im...